The Development and evaluation of a safety skill intervention for child victims of neglect

Child neglect is the least studied, yet most frequently indicated, type of child maltreatment. Still, there are few assessment and treatment methods specifically designed for victims of child neglect. Unintentional injuries have long remained the leading cause of death for children in the United States after the first year of life, and research suggests the majority of these child fatalities are actually the result of child neglect. Homes of neglectful families are often inundated with safety hazards but child-focused home safety skill interventions have yet to be developed. Thus, the present study focused on the development and initial evaluation of a child-focused home safety skills training program for victims of child neglect. The child-training was incorporated into Family Behavior Therapy (FBT), an in-home parent-focused treatment program for child neglect and maternal substance abuse. The original development and initial evaluation of the training in uncontrolled case trials are reviewed. The current study involved two controlled multiple baseline evaluations for child participants. Results after training indicated improvements in children\u27s skills relevant to ameliorating identified home hazards, and suggest the training is promising and worthy of future study

Financial Stress and Marital Quality: The Moderating Influence of Couple Communication

This study explores the negative relationship between financial stress and marital quality and examines couple communication as a moderator in this relationship. Using a sample of 373 married U.S. couples from the Flourishing Families Project, an Actor-Partner Interdependence Model (APIM) was run to determine the influence of husbands’ and wives’ financial stress on both their own and their partner’s reports of marital quality. Results found negative associations between both actor and partner reports of financial stress and marital quality. Couple communication did not moderate the associations between husbands’ and wives’ financial stress and wives’ marital quality. However, it did moderate the negative associations between both husbands’ and wives’ financial stress and husbands’ marital quality. Specifically, the deleterious relationship of financial stress to marital quality for husbands was significantly less severe when coupled with positive couple communication. Implications for financial therapists and avenues for future research are discussed

Perceived Family and Partner Support and the Work-Family Interface: A Meta-Analytic Review

This study employed meta-analytic techniques to elucidate the role of perceived partner and family support in four measures of the work-family interface. We extracted 183 effect sizes from 82 samples and a total of N = 36,226 individuals. We found perceived familial (partner and family) support was negatively associated with work-to-family conflict (r = -.099) and family-to-work conflict (r = -.178). It was positively associated with work-to-family enrichment (r = .173) and family-to-work enrichment (r = .378). Various sample-level moderators were investigated through meta regression and subgroup analyses, including whether the support measure was family or partner focused. Perceived family support showed larger magnitude associations with the two conflict outcome variables than partner support, while there were no significant differences between family and partner support and the two enrichment outcomes. The results suggest that familial support is an essential component of successfully minimizing work-family conflict and maximizing work-family enrichment, and that whether the measure of support is partner or family specific may impact the magnitude of results

The emergence of cognitive sex differences during adolescence : a longitudinal study

Cognitive sex differences have consistently been found in adulthood, with males excelling on visual-spatial tasks and females excelling on manual dexterity tasks. Although these differences are found in adulthood, they rarely exist before adolescence. The present study aims to document the emergence of cognitive sex differences in an adolescent sample. The first year of the study began when the adolescent sample was in the 7th grade. Cognitive measurements continued in the same sample once a year for five consecutive years. Participants were administered a battery of sex-sensitive tasks known to show sex differences in adulthood. In order to compare adult performance with adolescent performance, college-aged males and females were also tested once on the same battery of cognitive tasks

Use of a Multiplex Transcript Method for Analysis of Pseudomonas Aeruginosa Gene Expression Profiles in the Cystic Fibrosis Lung

The discovery of therapies that modulate Pseudomonas aeruginosa virulence or that can eradicate chronic P. aeruginosa lung infections associated with cystic fibrosis (CF) will be advanced by an improved understanding of P. aeruginosa behavior in vivo We demonstrate the use of multiplexed Nanostring technology to monitor relative abundances of P. aeruginosa transcripts across clinical isolates, in serial samples, and for the purposes of comparing microbial physiology in vitro and in vivo The expression of 75 transcripts encoded by genes implicated in CF lung disease was measured in a variety of P. aeruginosa strains as well as RNA serial sputum samples from four P. aeruginosa-colonized subjects with CF collected over 6 months. We present data on reproducibility, the results from different methods of normalization, and demonstrate high concordance between transcript relative abundance data obtained by Nanostring or transcriptome sequencing (RNA-Seq) analysis. Furthermore, we address considerations regarding sequence variation between strains during probe design. Analysis of P. aeruginosa grown in vitro identified transcripts that correlated with the different phenotypes commonly observed in CF clinical isolates. P. aeruginosa transcript profiles in RNA from CF sputum indicated alginate production in vivo, and transcripts involved in quorum-sensing regulation were less abundant in sputum than strains grown in the laboratory. P. aeruginosa gene expression patterns from sputum clustered closely together relative to patterns for laboratory-grown cultures; in contrast, laboratory-grown P. aeruginosa showed much greater transcriptional variation with only loose clustering of strains with different phenotypes. The clustering within and between subjects was surprising in light of differences in inhaled antibiotic and respiratory symptoms, suggesting that the pathways represented by these 75 transcripts are stable in chronic CF P. aeruginosa lung infections

Troubling "understanding mathematics-in-depth": Its role in the identity work of student-teachers in England

Copyright @ The Author(s) 2013. This article is published with open access at Springerlink.comThis article has been made available through the Brunel Open Access Publishing Fund.In this paper, we focus on an initiative in England devised to prepare non-mathematics graduates to train as secondary mathematics teachers through a 6-month Mathematics Enhancement Course (MEC) to boost their subject knowledge. The course documentation focuses on the need to develop “understanding mathematics in-depth” in students in order for them to become successful mathematics teachers. We take a poststructural approach, so we are not interested in asking what such an understanding is, about the value of this approach or about the effectiveness of the MECs in developing this understanding in their participants. Instead we explore what positions this discourse of “understanding mathematics in-depth” makes available to MEC students. We do this by looking in detail at the “identity work” of two students, analysing how they use and are used by this discourse to position themselves as future mathematics teachers. In doing so, we show how even benign-looking social practices such as “understanding mathematics in-depth” are implicated in practices of inclusion and exclusion. We show this through detailed readings of interviews with two participants, one of whom fits with the dominant discourses in the MEC and the other who, despite passing the MEC, experiences tensions between her national identity work and MEC discourses. We argue that it is vital to explore “identity work” within teacher education contexts to ensure that becoming a successful mathematics teacher is equally available to all.King’s College Londo

Urban Stream Burial Increases Watershed-Scale Nitrate Export

Nitrogen (N) uptake in streams is an important ecosystem service that reduces nutrient loading to downstream ecosystems. Here we synthesize studies that investigated the effects of urban stream burial on N-uptake in two metropolitan areas and use simulation modeling to scale our measurements to the broader watershed scale. We report that nitrate travels on average 18 times farther downstream in buried than in open streams before being removed from the water column, indicating that burial substantially reduces N uptake in streams. Simulation modeling suggests that as burial expands throughout a river network, N uptake rates increase in the remaining open reaches which somewhat offsets reduced N uptake in buried reaches. This is particularly true at low levels of stream burial. At higher levels of stream burial, however, open reaches become rare and cumulative N uptake across all open reaches in the watershed rapidly declines. As a result, watershed-scale N export increases slowly at low levels of stream burial, after which increases in export become more pronounced. Stream burial in the lower, more urbanized portions of the watershed had a greater effect on N export than an equivalent amount of stream burial in the upper watershed. We suggest that stream daylighting (i.e., uncovering buried streams) can increase watershed-scale N retention

TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages

Regulation of IFN signaling is critical in host recognition and response to pathogens while its dysregulation underlies the pathogenesis of several chronic diseases. STimulator of IFN Genes (STING) has been identified as a critical mediator of IFN inducing innate immune pathways, but little is known about direct coregulators of this protein. We report here that TMEM203, a conserved putative transmembrane protein, is an intracellular regulator of STING-mediated signaling. We show that TMEM203 interacts, functionally cooperates, and comigrates with STING following cell stimulation, which in turn leads to the activation of the kinase TBK1, and the IRF3 transcription factor. This induces target genes in macrophages, including IFN-β. Using Tmem203 knockout bone marrow-derived macrophages and transient knockdown of TMEM203 in human monocyte-derived macrophages, we show that TMEM203 protein is required for cGAMPinduced STING activation. Unlike STING, TMEM203 mRNA levels are elevated in T cells from patients with systemic lupus erythematosus, a disease characterized by the overexpression of type I interferons. Moreover, TMEM203 mRNA levels are associated with disease activity, as assessed by serum levels of the complement protein C3. Identification of TMEM203 sheds light into the control of STING-mediated innate immune responses, providing a potential novel mechanism for therapeutic interventions in STING-associated inflammatory diseases